Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
نویسندگان
چکیده
Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-γ.
منابع مشابه
AMP-activated protein kinase restricts IFN-γ signaling.
Inflammation in the CNS contributes to neurologic disorders. Neuroinflammation involves the release of inflammatory molecules from glial cells, such as astrocytes and microglia, and can lead to neuronal damage if unabated. In multiple sclerosis, peripheral immune cells, including IFN-γ-producing Th1 cells, infiltrate the CNS and are important in shaping the inflammatory microenvironment, in par...
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تاریخ انتشار 1999